After a woman whom she had a one-night stand with begins seizing in her apartment, Thirteen takes her to Princeton-Plainsboro. House and the team take on her case, with House using the case as an opportunity to explore Thirteen’s personal life. Thirteen finds that the patient has a long medical history and has seen many doctors over the years, eventuating in Thirteen finding out the patient only slept with her to get to House, who had been rejecting the woman as a patient for many years. Meanwhile, Lucas continues to keep on Wilson's trail.